Category:Medical - Revision history

Lera at 02:49, 18 March 2024

2024-03-18T02:49:27Z

← Older revision		Revision as of 02:49, 18 March 2024
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	= Medical Transition Pages =		= Medical Transition Pages =
	All people have both estrogen and testosterone (as well as other sex hormones) naturally occurring in their body and it is the levels of those hormones which cause the difference we see between male and female development. The blueprint for development ~~including~~ is encoded on the autosomal (non-sex) chromosomes and parts of it are activated or deactivated based on the effects of hormones. Transitioning with the use of hormone replacement therapy (HRT) acts on the tissues in your body and transforms your phenotype<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533072/</ref>: Sex hormones bind to sex hormone receptors in various cells and then translocate into the cell nucleus. In the nucleus, a ligand-bound sex hormone receptor acts a transcription factor by binding to the promoter region of genes containing a hormone responsive element (HRE), leading to regulation of gene expression.<ref>[https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes. https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes.]</ref>		All people have both estrogen and testosterone (as well as other sex hormones) naturally occurring in their body and it is the levels of those hormones which cause the difference we see between male and female development. The blueprint for development is encoded on the autosomal (non-sex) chromosomes and parts of it are activated or deactivated based on the effects of hormones. Transitioning with the use of hormone replacement therapy (HRT) acts on the tissues in your body and transforms your phenotype<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533072/</ref>: Sex hormones bind to sex hormone receptors in various cells and then translocate into the cell nucleus. In the nucleus, a ligand-bound sex hormone receptor acts a transcription factor by binding to the promoter region of genes containing a hormone responsive element (HRE), leading to regulation of gene expression.<ref>[https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes. https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes.]</ref>
	[[File:Transcriptional network of steroid hormone receptors.png\|center\|thumb\|[https://www.nature.com/articles/aps2014123 Transcriptional network of hormone receptors]]]		[[File:Transcriptional network of steroid hormone receptors.png\|center\|thumb\|[https://www.nature.com/articles/aps2014123 Transcriptional network of hormone receptors]]]
	The human body regulates levels of sex hormones using hypothalamic-pituitary-gonadal axis (HPG axis is the endo term used). The axis controls development, reproduction, and aging in animals. Gonadotropin-releasing hormone (GnRH) is secreted from the hypothalamus by GnRH-expressing neurons. The anterior portion of the pituitary gland produces luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone.		The human body regulates levels of sex hormones using hypothalamic-pituitary-gonadal axis (HPG axis is the endo term used). The axis controls development, reproduction, and aging in animals. Gonadotropin-releasing hormone (GnRH) is secreted from the hypothalamus by GnRH-expressing neurons. The anterior portion of the pituitary gland produces luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone.

Lera at 02:49, 18 March 2024

2024-03-18T02:49:07Z

← Older revision		Revision as of 02:49, 18 March 2024
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	= Medical Transition Pages =		= Medical Transition Pages =
	All people have both estrogen and testosterone (as well as other sex hormones) naturally occurring in their body and it is ~~different~~ levels of those hormones which cause the difference we see between male and female development. Transitioning with the use of hormone replacement therapy transforms your phenotype ~~by acting as a blueprint for tissues in the body~~: Sex hormones bind to sex hormone receptors and then translocate into the cell nucleus. In the nucleus, a ligand-bound sex hormone receptor acts a transcription factor by binding to the promoter region of genes containing a hormone responsive element (HRE), leading to regulation of gene expression.<ref>[https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes. https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes.]</ref>		All people have both estrogen and testosterone (as well as other sex hormones) naturally occurring in their body and it is the levels of those hormones which cause the difference we see between male and female development. The blueprint for development including is encoded on the autosomal (non-sex) chromosomes and parts of it are activated or deactivated based on the effects of hormones. Transitioning with the use of hormone replacement therapy (HRT) acts on the tissues in your body and transforms your phenotype<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533072/</ref>: Sex hormones bind to sex hormone receptors in various cells and then translocate into the cell nucleus. In the nucleus, a ligand-bound sex hormone receptor acts a transcription factor by binding to the promoter region of genes containing a hormone responsive element (HRE), leading to regulation of gene expression.<ref>[https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes. https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes.]</ref>
	[[File:Transcriptional network of steroid hormone receptors.png\|center\|thumb\|[https://www.nature.com/articles/aps2014123 Transcriptional network of hormone receptors]]]		[[File:Transcriptional network of steroid hormone receptors.png\|center\|thumb\|[https://www.nature.com/articles/aps2014123 Transcriptional network of hormone receptors]]]
	The human body regulates levels of sex hormones using hypothalamic-pituitary-gonadal axis (HPG axis is the endo term used). The axis controls development, reproduction, and aging in animals. Gonadotropin-releasing hormone (GnRH) is secreted from the hypothalamus by GnRH-expressing neurons. The anterior portion of the pituitary gland produces luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone.		The human body regulates levels of sex hormones using hypothalamic-pituitary-gonadal axis (HPG axis is the endo term used). The axis controls development, reproduction, and aging in animals. Gonadotropin-releasing hormone (GnRH) is secreted from the hypothalamus by GnRH-expressing neurons. The anterior portion of the pituitary gland produces luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone.

Lera at 01:32, 3 December 2023

2023-12-03T01:32:27Z

← Older revision		Revision as of 01:32, 3 December 2023
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	= Medical Transition Pages =		= Medical Transition Pages =
	~~This category contains all medical transition topics~~, ~~including~~ hormones, ~~operations~~, and ~~more~~. ~~This will not cover topics like skin care~~, ~~exercise~~, ~~makeup~~, ~~fashion~~, and ~~more~~. ~~You can find those in~~ the ~~nonmedical section~~ of the ~~website~~.		All people have both estrogen and testosterone (as well as other sex hormones) naturally occurring in their body and it is different levels of those hormones which cause the difference we see between male and female development. Transitioning with the use of hormone replacement therapy transforms your phenotype by acting as a blueprint for tissues in the body: Sex hormones bind to sex hormone receptors and then translocate into the cell nucleus. In the nucleus, a ligand-bound sex hormone receptor acts a transcription factor by binding to the promoter region of genes containing a hormone responsive element (HRE), leading to regulation of gene expression.<ref>[https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes. https://pubmed.ncbi.nlm.nih.gov/16273365/#:~:text=Nuclear%20sex%20hormone%20receptors%20are,the%20expression%20of%20target%20genes.]</ref>
			[[File:Transcriptional network of steroid hormone receptors.png\|center\|thumb\|[https://www.nature.com/articles/aps2014123 Transcriptional network of hormone receptors]]]
			The human body regulates levels of sex hormones using hypothalamic-pituitary-gonadal axis (HPG axis is the endo term used). The axis controls development, reproduction, and aging in animals. Gonadotropin-releasing hormone (GnRH) is secreted from the hypothalamus by GnRH-expressing neurons. The anterior portion of the pituitary gland produces luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and the gonads produce estrogen and testosterone.
			[[File:HPG axis.png\|center\|thumb\|[https://www.intechopen.com/chapters/75387 HPG Axis]]]
			Modern HRT utilizes "bioidentical" medication which means it has the same chemical structure as the endogenous hormones which your body naturally produces. Physiological data and clinical outcomes demonstrate that bioidentical hormones are associated with lower risks, including the risk of breast cancer and cardiovascular disease, and are more efficacious than their synthetic and animal-derived counterparts.<ref>https://www.tandfonline.com/doi/abs/10.3810/pgm.2009.01.1949</ref>

			=== Medical Guidelines ===
			'''The Journal of Clinical Endocrinology & Metabolism:''' [https://academic.oup.com/jcem/article/102/11/3869/4157558 Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline.]

			'''World Professional Association for Transgender Health:''' [https://www.tandfonline.com/doi/pdf/10.1080/26895269.2022.2100644 Standards of Care for the Health of Transgender and Gender Diverse People, Version 8]

			Please note that the WPATH is a standard used by many healthcare providers including public health services and health insurance companies with policies for covered trans treatments. As of September 2022 the release of SOC 8 includes the following: AMAB: facial feminization surgery (including chondrolaryngoplasty/vocal cord surgery), gender-affirming breast surgery, body contouring procedures, orchiectomy, vagino/vulvoplasty (with/without depth), aesthetic procedures, and procedures designed to prepare individuals for surgery (i.e., hair removal).


			For other detailed information, this is currently the best source on transfem hormone therapy: https://transfemscience.org/articles/transfem-intro/

Plants: Protected "Category:Medical" ([Edit=Allow only autoconfirmed users] (indefinite) [Move=Allow only administrators] (indefinite))

2023-11-17T06:34:43Z

Protected "Category:Medical" ([Edit=Allow only autoconfirmed users] (indefinite) [Move=Allow only administrators] (indefinite))

← Older revision

Revision as of 06:34, 17 November 2023

Plants at 03:33, 12 November 2023

2023-11-12T03:33:14Z

← Older revision		Revision as of 03:33, 12 November 2023
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	= Medical Transition Pages =		= Medical Transition Pages =
	~~Pages pertaining to~~ medical transition ~~resources~~.		This category contains all medical transition topics, including hormones, operations, and more. This will not cover topics like skin care, exercise, makeup, fashion, and more. You can find those in the nonmedical section of the website.

	~~If you are entirely new to medical transition~~, ~~check out~~ the ~~[[Intro to Medical Transition]] page. If you need something specific, check out~~ the ~~links below~~.

Plants: making medical transition page

2023-11-06T01:33:58Z

making medical transition page

← Older revision		Revision as of 01:33, 6 November 2023
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	Pages pertaining to medical transition resources.		Pages pertaining to medical transition resources.

	If you are entirely new to medical transition, [[Intro to ~~HRT~~]] ~~is a good place to start~~.		If you are entirely new to medical transition, check out the [[Intro to Medical Transition]] page. If you need something specific, check out the links below.

Plants: testing

2023-11-06T01:24:38Z

testing

← Older revision		Revision as of 01:24, 6 November 2023
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	= Medical Transition Pages =		= Medical Transition Pages =
	Pages pertaining to medical transition resources.		Pages pertaining to medical transition resources.

			If you are entirely new to medical transition, [[Intro to HRT]] is a good place to start.

Unusualcrow: Redundant links, use Category:name on pages to add them.

2023-11-05T22:16:57Z

Redundant links, use Category:name on pages to add them.

← Older revision		Revision as of 22:16, 5 November 2023
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	= Medical Transition Pages =		= Medical Transition Pages =
	Pages pertaining to medical transition resources.		Pages pertaining to medical transition resources.

	~~[[Intro to HRT]]~~

	~~[[Estradiol]]~~

Soap: /* Medical Transition Pages */

2023-11-05T20:06:02Z

Medical Transition Pages

← Older revision		Revision as of 20:06, 5 November 2023
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	= Medical Transition Pages =		= Medical Transition Pages =
	Pages pertaining to medical transition resources.		Pages pertaining to medical transition resources.

			[[Intro to HRT]]

	[[Estradiol]]		[[Estradiol]]

	~~[[Intro to HRT]]~~

Soap: /* Medical Transition Pages */

2023-11-05T20:05:45Z

Medical Transition Pages

← Older revision		Revision as of 20:05, 5 November 2023
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	[[Estradiol]]		[[Estradiol]]

			[[Intro to HRT]]