Intro to HRT - Revision history

Unusualcrow: style and minor info edits

2024-09-16T12:34:56Z

style and minor info edits

← Older revision		Revision as of 12:34, 16 September 2024
Line 123:		Line 123:
	Blood tests are the only effective way to measure these levels and are extremely important in minimizing the risks of HRT and maximizing its effectiveness. We will talk about how to manage being in a situation where you cannot access bloodwork. This is not impossible, but we highly recommend against it.		Blood tests are the only effective way to measure these levels and are extremely important in minimizing the risks of HRT and maximizing its effectiveness. We will talk about how to manage being in a situation where you cannot access bloodwork. This is not impossible, but we highly recommend against it.

	~~Now, onto the fun stuff: what to take, and how to dose it.~~		The most efficient method of administering estradiol is via injecting a solution. Pills are much less efficient, and patches and gels are generally somewhere between the two in effectiveness.

	The most efficient ~~way~~ is injecting a solution~~, pills~~ are less efficient and patches and gels are ~~intermediate~~.

	=== Injection monotherapy ===		=== Injection monotherapy ===
	~~The big one.~~ Estradiol is the most biologically active estrogen and heavily contributes to feminization. On top of this, it contributes to the suppression of testosterone.		Estradiol is the most biologically active estrogen and heavily contributes to feminization. On top of this, it contributes to the suppression of testosterone.

	In estradiol-only HRT, also known as monotherapy, estradiol alone provides both feminization and suppression of testosterone into female ranges. This is possible because of estradiol's suppressing effect on testosterone by itself at high enough levels. Monotherapy removes or reduces certain potential risks and side effects that may be caused by antiandrogens used to help with testosterone suppression, but usually requires more estradiol and is much harder to achieve with specific routes of administration such as oral or transdermal.		In estradiol-only HRT, also known as monotherapy, estradiol alone provides both feminization and suppression of testosterone into female ranges. This is possible because of estradiol's suppressing effect on testosterone by itself at high enough levels. Monotherapy removes or reduces certain potential risks and side effects that may be caused by antiandrogens used to help with testosterone suppression, but usually requires more estradiol and is much harder to achieve with specific routes of administration such as oral or transdermal.
Line 170:		Line 168:

	=== Antiandrogens AKA testosterone blockers ===		=== Antiandrogens AKA testosterone blockers ===
	Antiandrogens are medications that counteract the effects of androgens—male sex hormones such as testosterone or DHT. High-dose estradiol is an effective antiandrogen, but for some patients it may be very hard or impossible to get proper levels without an antiandrogen. Common antiandrogens for feminizing HRT are cyproterone acetate, spironolactone, and bicalutamide. These medications all work in different ways to suppress androgens.		Antiandrogens are medications that counteract the effects of androgens—male sex hormones such as testosterone or DHT. High-dose estradiol is an effective antiandrogen, but for some patients it may be very hard or impossible to get proper levels without an additional antiandrogen. Common antiandrogens for feminizing HRT are cyproterone acetate, spironolactone, and bicalutamide. These medications all work in different ways to suppress androgens. Compared to injection monotherapy, the accompanying dose of estradiol is usually lower when an additional antiandrogen is used.

	Bicalutamide is an antiandrogen also used to treat prostate cancer by blocking the effects of testosterone, which in turn slows or stops the growth of cancerous cells.<ref>Mayo Clinic. (Nov. 01, 2023). Bicalutamide (Oral Route) - Side Effects. Retrieved from <nowiki>https://www.mayoclinic.org/drugs-supplements/bicalutamide-oral-route/side-effects/drg-20072486?p=1</nowiki></ref> This testosterone blocking effect is desirable in feminizing HRT, and as such, bicalutamide is a common choice of antiandrogen. It is commonly dosed at 25-50mg/day. Keep in mind when taking bicalutamide that it does not block testosterone production; testosterone blood levels may significantly increase.<ref>Cockshott I. D. (2004). Bicalutamide: clinical pharmacokinetics and metabolism. ''Clinical pharmacokinetics'', ''43''(13), 855–878. <nowiki>https://doi.org/10.2165/00003088-200443130-00003</nowiki></ref> Instead, it prevents testosterone from attaching to its receptors. Although you still have it in your blood, on a proper dosage you will not experience any androgenic effects.		Bicalutamide is an antiandrogen also used to treat prostate cancer by blocking the effects of testosterone, which in turn slows or stops the growth of cancerous cells.<ref>Mayo Clinic. (Nov. 01, 2023). Bicalutamide (Oral Route) - Side Effects. Retrieved from <nowiki>https://www.mayoclinic.org/drugs-supplements/bicalutamide-oral-route/side-effects/drg-20072486?p=1</nowiki></ref> This testosterone blocking effect is desirable in feminizing HRT, and as such, bicalutamide is a common choice of antiandrogen. It is commonly dosed at 25-50mg/day. Keep in mind when taking bicalutamide that it does not block testosterone production; testosterone blood levels may significantly increase.<ref>Cockshott I. D. (2004). Bicalutamide: clinical pharmacokinetics and metabolism. ''Clinical pharmacokinetics'', ''43''(13), 855–878. <nowiki>https://doi.org/10.2165/00003088-200443130-00003</nowiki></ref> Instead, it prevents testosterone from attaching to its receptors. Although you still have it in your blood, on a proper dosage you will not experience any androgenic effects.

Kenopsia at 16:14, 12 February 2024

2024-02-12T16:14:09Z

← Older revision		Revision as of 16:14, 12 February 2024
Line 111:		Line 111:
	Again, the goal of feminizing HRT is to bring your hormone levels (estradiol and testosterone in particular) from your current male range to that of a healthy cisgender woman. On top of this, there are some medications and other hormones we will cover, such as antiandrogens, progestogens, and other niche or specific medications, including hair loss treatments and more experimental methods for feminization.		Again, the goal of feminizing HRT is to bring your hormone levels (estradiol and testosterone in particular) from your current male range to that of a healthy cisgender woman. On top of this, there are some medications and other hormones we will cover, such as antiandrogens, progestogens, and other niche or specific medications, including hair loss treatments and more experimental methods for feminization.

	Before we talk about specific medications, you need to have a basic understanding of the target hormone levels. According to the Journal of Clinical Endocrinology for feminization to be effective you should be within the levels of a premenopausal female:		Before we talk about specific medications, you need to have a basic understanding of the target hormone levels. According to the Journal of Clinical Endocrinology, for feminization to be effective you should be within the levels of a premenopausal female:

	'''100-200 pg/ml estradiol & <50 ng/dl testosterone.'''<ref>Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, Guy G T’Sjoen, Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline, ''The Journal of Clinical Endocrinology & Metabolism'', Volume 102, Issue 11, 1 November 2017, Pages 3869–3903, https://doi.org/10.1210/jc.2017-01658</ref>		'''100-200 pg/ml estradiol & <50 ng/dl testosterone.'''<ref>Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, Guy G T’Sjoen, Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline, ''The Journal of Clinical Endocrinology & Metabolism'', Volume 102, Issue 11, 1 November 2017, Pages 3869–3903, https://doi.org/10.1210/jc.2017-01658</ref>

Lera: Typo xd

2024-02-05T19:16:07Z

Typo xd

← Older revision		Revision as of 19:16, 5 February 2024
Line 123:		Line 123:
	Blood tests are the only effective way to measure these levels and are extremely important in minimizing the risks of HRT and maximizing its effectiveness. We will talk about how to manage being in a situation where you cannot access bloodwork. This is not impossible, but we highly recommend against it.		Blood tests are the only effective way to measure these levels and are extremely important in minimizing the risks of HRT and maximizing its effectiveness. We will talk about how to manage being in a situation where you cannot access bloodwork. This is not impossible, but we highly recommend against it.

	Now, onto the fun stuff: what to take, and how to dose it. T		Now, onto the fun stuff: what to take, and how to dose it.

	The most efficient way is injecting a solution, pills are less efficient and patches and gels are intermediate.		The most efficient way is injecting a solution, pills are less efficient and patches and gels are intermediate.

Lera: misworded last edit

2024-02-05T19:15:40Z

misworded last edit

← Older revision		Revision as of 19:15, 5 February 2024
Line 122:		Line 122:

	Blood tests are the only effective way to measure these levels and are extremely important in minimizing the risks of HRT and maximizing its effectiveness. We will talk about how to manage being in a situation where you cannot access bloodwork. This is not impossible, but we highly recommend against it.		Blood tests are the only effective way to measure these levels and are extremely important in minimizing the risks of HRT and maximizing its effectiveness. We will talk about how to manage being in a situation where you cannot access bloodwork. This is not impossible, but we highly recommend against it.
	~~Now, onto the fun stuff: what to take, and how to dose it.~~

	Now onto the ~~way you~~ take it and how to dose it. The most efficient way is injecting a solution, pills are less efficient and patches and gels are intermediate.		Now, onto the fun stuff: what to take, and how to dose it. T

			The most efficient way is injecting a solution, pills are less efficient and patches and gels are intermediate.

	=== Injection monotherapy ===		=== Injection monotherapy ===

Lera at 04:45, 2 February 2024

2024-02-02T04:45:22Z

← Older revision		Revision as of 04:45, 2 February 2024
Line 111:		Line 111:
	Again, the goal of feminizing HRT is to bring your hormone levels (estradiol and testosterone in particular) from your current male range to that of a healthy cisgender woman. On top of this, there are some medications and other hormones we will cover, such as antiandrogens, progestogens, and other niche or specific medications, including hair loss treatments and more experimental methods for feminization.		Again, the goal of feminizing HRT is to bring your hormone levels (estradiol and testosterone in particular) from your current male range to that of a healthy cisgender woman. On top of this, there are some medications and other hormones we will cover, such as antiandrogens, progestogens, and other niche or specific medications, including hair loss treatments and more experimental methods for feminization.

	Before we talk about specific medications, you need to have a basic understanding of the target hormone levels. ~~For~~ feminization to be effective, you should be within the levels of a premenopausal female:		Before we talk about specific medications, you need to have a basic understanding of the target hormone levels. According to the Journal of Clinical Endocrinology for feminization to be effective you should be within the levels of a premenopausal female:

	'''100-200 pg/ml estradiol & <50 ng/dl testosterone.'''<ref>Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, Guy G T’Sjoen, Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline, ''The Journal of Clinical Endocrinology & Metabolism'', Volume 102, Issue 11, 1 November 2017, Pages 3869–3903, https://doi.org/10.1210/jc.2017-01658</ref>		'''100-200 pg/ml estradiol & <50 ng/dl testosterone.'''<ref>Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, Guy G T’Sjoen, Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline, ''The Journal of Clinical Endocrinology & Metabolism'', Volume 102, Issue 11, 1 November 2017, Pages 3869–3903, https://doi.org/10.1210/jc.2017-01658</ref>

			with some variation depending on the method you take your levels should approximate the menstrual cycle:

			[[File:Cis menstrual cycle.png\|frameless\|600x600px]]

			higher levels do not cause greater feminization and may have even have a counterproductive effect as estrogen may have an inhibitory effect on cell proliferation at a higher level. <ref>https://www.sciencedirect.com/science/article/abs/pii/S0960076006001567</ref>

	Blood tests are the only effective way to measure these levels and are extremely important in minimizing the risks of HRT and maximizing its effectiveness. We will talk about how to manage being in a situation where you cannot access bloodwork. This is not impossible, but we highly recommend against it.		Blood tests are the only effective way to measure these levels and are extremely important in minimizing the risks of HRT and maximizing its effectiveness. We will talk about how to manage being in a situation where you cannot access bloodwork. This is not impossible, but we highly recommend against it.
			Now, onto the fun stuff: what to take, and how to dose it.

	Now, onto the ~~fun stuff: what to~~ take, and how to dose it.		Now onto the way you take it and how to dose it. The most efficient way is injecting a solution, pills are less efficient and patches and gels are intermediate.

	=== Injection monotherapy ===		=== Injection monotherapy ===

Lera at 07:14, 3 December 2023

2023-12-03T07:14:54Z

← Older revision		Revision as of 07:14, 3 December 2023
Line 17:		Line 17:
	For other countries you should try looking at [https://www.transgendermap.com/resources/international/ this map] of international transgender resources or [https://www.reddit.com/r/Trans_Resources/wiki/country_specific/index/ this reddit page.]		For other countries you should try looking at [https://www.transgendermap.com/resources/international/ this map] of international transgender resources or [https://www.reddit.com/r/Trans_Resources/wiki/country_specific/index/ this reddit page.]

	Alternatively you can ~~order~~ your own ~~hormone~~ medication online and administer it yourself. [https://cryptpad.fr/pad/#/2/pad/view/CXeX4FIb40uF6zxA7gCqTEtR2wMNs2MZKu73Kvtv-Sw/ ~~Find out how here~~.]		Alternatively you can get your own medication online and administer it yourself. Order from here https://diyhrt.market/stores/ and use [https://cryptpad.fr/pad/#/2/pad/view/CXeX4FIb40uF6zxA7gCqTEtR2wMNs2MZKu73Kvtv-Sw/ this] guide.

	== What can HRT do for me? ==		== What can HRT do for me? ==

Lera at 01:58, 3 December 2023

2023-12-03T01:58:39Z

← Older revision		Revision as of 01:58, 3 December 2023
Line 4:		Line 4:

	In this page, we will cover how HRT can be used in AMAB (assigned male at birth) patients for gender affirmation, a type of HRT known as feminizing HRT. Feminizing HRT can have profound effects even on patients who are post-puberty, and has the potential to significantly improve quality of life for transfeminine individuals.		In this page, we will cover how HRT can be used in AMAB (assigned male at birth) patients for gender affirmation, a type of HRT known as feminizing HRT. Feminizing HRT can have profound effects even on patients who are post-puberty, and has the potential to significantly improve quality of life for transfeminine individuals.

			== How to get HRT ==
			Official transition routes for gender/sex reassignment therapy vary by country and the healthcare standards applicable there. Requirements for it can go as high as psychological evaluation for a diagnosis of gender dysphoria to as low as merely giving informed consent. You need to research available options in your country to find the most accessible method for you. Try strict searching "trans" "healthcare" "[your country]" see if you can connect with anyone who transitioned from where you live.

			* South America http://redlactrans.org.ar/site/
			* USA https://www.plannedparenthood.org/get-care/our-services/transgender-hormone-therapy
			* Canada https://cpath.ca/en/
			* Australia https://auspath.org.au/
			* UK https://www.gendergp.com/help-centre/gendergp-service-costs/
			* Europe https://tgeu.org/trans-health-map-2022/

			For other countries you should try looking at [https://www.transgendermap.com/resources/international/ this map] of international transgender resources or [https://www.reddit.com/r/Trans_Resources/wiki/country_specific/index/ this reddit page.]

			Alternatively you can order your own hormone medication online and administer it yourself. [https://cryptpad.fr/pad/#/2/pad/view/CXeX4FIb40uF6zxA7gCqTEtR2wMNs2MZKu73Kvtv-Sw/ Find out how here.]

	== What can HRT do for me? ==		== What can HRT do for me? ==

Lera at 07:19, 26 November 2023

2023-11-26T07:19:08Z

← Older revision		Revision as of 07:19, 26 November 2023
Line 1:		Line 1:
	[[Category:Medical\|~~Sort~~]]		[[Category:Medical\|A]]

	'''Hormone replacement therapy''', or HRT, is a relatively common medical treatment used in many contexts. Despite what many may think, this is not a new or experimental practice, nor is it exclusive to transgender individuals. Hormone replacement therapy has been used for over half a century, starting its use in the 1960s and is widely popular in treating menopause in AFAB (assigned female at birth) patients.		'''Hormone replacement therapy''', or HRT, is a relatively common medical treatment used in many contexts. Despite what many may think, this is not a new or experimental practice, nor is it exclusive to transgender individuals. Hormone replacement therapy has been used for over half a century, starting its use in the 1960s and is widely popular in treating menopause in AFAB (assigned female at birth) patients.

Lera at 07:18, 26 November 2023

2023-11-26T07:18:29Z

← Older revision		Revision as of 07:18, 26 November 2023
Line 1:		Line 1:
	[[Category:Medical]]		[[Category:Medical\|Sort]]

	'''Hormone replacement therapy''', or HRT, is a relatively common medical treatment used in many contexts. Despite what many may think, this is not a new or experimental practice, nor is it exclusive to transgender individuals. Hormone replacement therapy has been used for over half a century, starting its use in the 1960s and is widely popular in treating menopause in AFAB (assigned female at birth) patients.		'''Hormone replacement therapy''', or HRT, is a relatively common medical treatment used in many contexts. Despite what many may think, this is not a new or experimental practice, nor is it exclusive to transgender individuals. Hormone replacement therapy has been used for over half a century, starting its use in the 1960s and is widely popular in treating menopause in AFAB (assigned female at birth) patients.

Plants: Protected "Intro to HRT" ([Edit=Allow only autoconfirmed users] (indefinite))

2023-11-17T06:36:19Z

Protected "Intro to HRT" ([Edit=Allow only autoconfirmed users] (indefinite))

← Older revision

Revision as of 06:36, 17 November 2023