Estrogen Conversion and Receptors: Difference between revisions

From estrogen.fyi
(created page for estrogen conversions and receptors)
 
No edit summary
 
(One intermediate revision by the same user not shown)
Line 1: Line 1:
[[category:medical]]
The main feminizing effects of estrogen depend on sex-hormone receptors being present in cells and hormone molecules being free to bind to them to affect gene expression. Since sex-hormones also regulate receptor expression<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934771/</ref>, increasing the amount of receptors or hormone available for binding is thus a desirable goal for feminizing HRT.<ref>https://springerplus.springeropen.com/articles/10.1186/2193-1801-2-214</ref>
The main feminizing effects of estrogen depend on sex-hormone receptors being present in cells and hormone molecules being free to bind to them to affect gene expression. Since sex-hormones also regulate receptor expression<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934771/</ref>, increasing the amount of receptors or hormone available for binding is thus a desirable goal for feminizing HRT.<ref>https://springerplus.springeropen.com/articles/10.1186/2193-1801-2-214</ref>


Estradiol has a pathway of being synthesized from testosterone in the body through an enzyme called aromatase which allows for certain levels of testosterone to circulate and still be converted to estrogen.  
Estradiol has a pathway of being synthesized from testosterone in the body through an enzyme called aromatase which allows for certain levels of testosterone to circulate and still be converted to estrogen.<ref>https://www.ncbi.nlm.nih.gov/books/NBK278933/</ref>


[[File:Hormone conversions.png|frameless|400x400px]][[File:Aromatase Conversion.jpg|frameless|480x480px]]
[[File:Hormone conversions.png|frameless|400x400px]][[File:Aromatase Conversion.jpg|frameless|480x480px]]
This conversion of sex-hormones has an important effect on sites such as the breasts, fat, bones and brain which are affected by local synthesis of estradiol acting directly on the tissues<ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519084/</ref>.<ref>https://academic.oup.com/endo/article/142/11/4589/2988522?login=false</ref> <ref>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286233/</ref>

Latest revision as of 04:54, 18 March 2024


The main feminizing effects of estrogen depend on sex-hormone receptors being present in cells and hormone molecules being free to bind to them to affect gene expression. Since sex-hormones also regulate receptor expression[1], increasing the amount of receptors or hormone available for binding is thus a desirable goal for feminizing HRT.[2]

Estradiol has a pathway of being synthesized from testosterone in the body through an enzyme called aromatase which allows for certain levels of testosterone to circulate and still be converted to estrogen.[3]

This conversion of sex-hormones has an important effect on sites such as the breasts, fat, bones and brain which are affected by local synthesis of estradiol acting directly on the tissues[4].[5] [6]